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Nature Made SAM-e Complete 400 mg. (60 Tablets)

Vitamins & Supplements
  • 400 mg. of SAM-e Per Dose
  • Helps Support a Healthy Mood in as Little as 7–14 Days When Taken Daily
  • Helps Support Joint Comfort
  • May Help Support Muscle Comfort and Liver Function
  • Start By Taking 1 Tablet Daily With Water on an Empty Stomach

Nature Made® SAM-e Complete®** 400 mg can help replenish your SAM-e levels and help support a healthy mood. Nature Made is the #1 best-selling brand of SAM-e supplements. It’s backed by our satisfaction guarantee, and you will receive your money back if you find that it does not work for you.

  • 400 mg of SAM-e (S-adenosylmethionine Tosylate Disulfate)
  • Helps support a healthy mood in as little as 7-14 days when taken daily
  • Helps support joint comfort
  • May help support muscle comfort & liver function
  • #1 Pharmacist Recommended Vitamin & Supplement Brand*

Factors such as age, certain health conditions, and poor diet can impact the amount of SAM-e found in the body.

SAM-e, or S-adenosylmethionine, is a compound naturally produced in the body that may increase levels of neurotransmitters, or brain chemicals, responsible for mood.†1,2 When levels are low, a SAM-e supplement can help restore the body’s supply of SAM-e.

Therefore, SAM-e is recommended to help support a healthy mood. SAM-e has been shown to work in as little as 7 to 14 days when taken daily as directed. However, if you are experiencing symptoms of a low mood, see a physician for proper guidance.

SAM-e helps support joint comfort.†,3 SAM-e provides a source of dietary sulfur, which plays a role in joint support. Sulfur is a mineral used by the body in connective tissue and joint cartilage.

Although generally considered safe, SAM-e has not been evaluated in children or pregnant or lactating women. People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide, should not take any product containing SAM-e except under a doctor's supervision.

SAM-e should not be used when taking St. John's Wort. SAM-e should be used with caution and only under your healthcare provider's supervision when taking MAOI drugs, like Marplan, Nardil, Parnate, Manerix. Individuals on other medications should consult their primary healthcare provider prior to starting SAM-e to check for other potential interactions.


Suggested Use: Adults start by taking 1 tablet daily with water on an empty stomach. If benefits are not achieved within two weeks, you may require a higher level of supplementation. To determine the proper level for you, gradually increase the number of tablets (maximum 1600 mg/day) until benefits are achieved.

 S-adenosylmethionine Tosylate Disulfate, Cellulose Gel, Methacrylic Acid Copolymer, Stearic Acid, Silicon Dioxide, Triethyl Citrate, Magnesium Stearate, Color Added, Mannitol, Sodium Starch Glycolate.

 People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide, should not take any product containing SAM-e except under a physician's supervision. If you are pregnant, nursing, or taking any medications including antidepressants, consult your physician before use.

The foil blister pack ensures safety and freshness. Do not use if tamper-evident printed foil seal over tablets is broken.

Store tightly closed, in a cool, dry place, out of reach of children.


We can ship to virtually any address in the world. Note that there are restrictions on some products, and some products cannot be shipped to international destinations.

When you place an order, we will estimate shipping and delivery dates for you based on the availability of your items and the shipping options you choose. We Offer a very competitive shipping rates to Canada, Europe, and the rest of the World!

Our goal is to offer you the best shipping options, no matter where you live. Every day, we deliver to hundreds of customers across the world, ensuring that we provide the very highest levels of responsiveness to you at all times.

Returns Policy

If you are not completely satisfied with your order, We offer a 30-days 100% money-back guarantee with no-question-asked. If 30 days have gone by since your delivery, unfortunately, we can’t offer you a refund or exchange. To be eligible for a return, your item must be unused and in the same condition that you received it. It must also be in the original packaging.

You may return most new, unopened items within 30 days of delivery for a full refund. We'll also pay the return shipping costs if the return is a result of our error (you received an incorrect or defective item, etc.).

If you need to return an item, simply login to your account, view the order using the 'Complete Orders' link under the My Account menu and click the Return Item(s) button. We'll notify you via e-mail of your refund once we've received and processed the returned item.

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